Linda J Van Eldik Selected Research

minozac

7/2009	Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.
9/2007	Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation.

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Linda J Van Eldik Research Topics

Disease

37	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2002
24	Neuroinflammatory Diseases 10/2019 - 01/2003
12	Cognitive Dysfunction 01/2021 - 12/2011
11	Inflammation (Inflammations) 01/2016 - 01/2004
10	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 01/2002
8	Dementia (Dementias) 01/2021 - 12/2011
6	Disease Progression 04/2015 - 01/2004
5	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2021 - 06/2008
5	Amyloid Plaque 01/2018 - 01/2004
3	Brain Injuries (Brain Injury) 01/2021 - 08/2014
3	Hippocampal Sclerosis 01/2018 - 05/2011
3	Tauopathies 01/2018 - 12/2016
3	Seizures (Absence Seizure) 05/2011 - 09/2007
2	Hyperhomocysteinemia 01/2022 - 09/2020
2	Proteostasis Deficiencies 10/2020 - 01/2020
2	Brain Diseases (Brain Disorder) 01/2019 - 05/2016
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 07/2015 - 05/2011
2	Craniocerebral Trauma (Head Injury) 04/2015 - 06/2008
2	Neurologic Manifestations (Neurological Manifestations) 08/2014 - 09/2007
2	Central Nervous System Diseases (CNS Diseases) 11/2009 - 12/2008
1	Cerebral Hemorrhage 01/2021
1	Injection Site Reaction 01/2021
1	Amyloidosis 09/2020
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2020
1	TDP-43 Proteinopathies 01/2020
1	Chronic Traumatic Encephalopathy 01/2018
1	Pain (Aches) 01/2016
1	Closed Head Injuries 01/2016
1	Hyperalgesia 01/2016
1	Sclerosis 07/2015
1	Epilepsy (Aura) 07/2015
1	Disease Susceptibility (Diathesis) 04/2015
1	Insulin Resistance 08/2014
1	Obesity 08/2014
1	Hereditary Spastic Paraplegia 12/2013
1	Pelizaeus-Merzbacher Disease 12/2013
1	Gliosis 04/2013
1	Acute Disease 09/2009
1	Neuroblastoma 12/2008

Drug/Important Bio-Agent (IBA)

27	CytokinesIBA 01/2021 - 01/2002
13	Pharmaceutical PreparationsIBA 01/2021 - 01/2002
13	Proteins (Proteins, Gene)FDA Link 10/2020 - 01/2004
12	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2004
8	Apolipoproteins E (ApoE)IBA 01/2021 - 01/2004
8	Amyloid beta-PeptidesIBA 01/2013 - 01/2003
7	ApolipoproteinsIBA 01/2021 - 01/2004
7	Biomarkers (Surrogate Marker)IBA 01/2018 - 11/2004
6	Phosphotransferases (Kinase)IBA 01/2017 - 07/2002
4	Apolipoprotein E4IBA 05/2015 - 01/2004
4	Peptides (Polypeptides)IBA 05/2015 - 01/2004
4	Protein Isoforms (Isoforms)IBA 04/2015 - 05/2003
4	Protein Kinases (Protein Kinase)IBA 04/2015 - 05/2003
3	LipidsIBA 01/2021 - 01/2019
3	ChemokinesIBA 01/2016 - 06/2008
3	Apolipoprotein E3IBA 05/2015 - 01/2004
3	EnzymesIBA 12/2011 - 01/2003
2	Myosin-Light-Chain KinaseIBA 10/2019 - 10/2005
2	Biological ProductsIBA 01/2017 - 05/2016
2	p38 Mitogen-Activated Protein KinasesIBA 12/2016 - 01/2004
2	Glial Fibrillary Acidic ProteinIBA 01/2016 - 07/2004
2	Eosine Yellowish-(YS) (Eosin)IBA 07/2015 - 05/2011
2	Hormones (Hormone)IBA 10/2014 - 08/2014
2	minozacIBA 07/2009 - 09/2007
2	Interleukin-1 (Interleukin 1)IBA 06/2005 - 02/2005
1	SolutionsIBA 01/2021
1	TT-301IBA 01/2021
1	SynucleinsIBA 10/2020
1	HomocysteineIBA 09/2020
1	Vitamin B Complex (B Vitamins)IBA 09/2020
1	alpha 2 subunit adaptor protein complex 2IBA 01/2020
1	Adaptor Protein Complex 2IBA 01/2020
1	Mucin-6IBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	MW01-18-150SRMIBA 01/2017
1	Mitogen-Activated Protein KinasesIBA 01/2017
1	tau Proteins (tau Protein)IBA 12/2016
1	CX3C Chemokine Receptor 1IBA 12/2016
1	DNA-Binding Proteins (DNA Binding Protein)IBA 05/2016
1	LigandsIBA 01/2016
1	CarrageenanIBA 01/2016
1	salicylhydroxamic acid (SHAM)IBA 01/2016
1	Arginine (L-Arginine)FDA Link 01/2016
1	Interleukin-6 (Interleukin 6)IBA 01/2016
1	Prostaglandin E Receptors (Prostaglandin E Receptor)IBA 01/2016
1	Hematoxylin (Haematoxylon)IBA 07/2015
1	Coloring Agents (Dyes)IBA 07/2015
1	Alanine (L-Alanine)FDA Link 02/2015
1	Threonine (L-Threonine)FDA Link 02/2015
1	Interleukin-10 (Interleukin 10)IBA 10/2014
1	Insulin (Novolin)FDA Link 08/2014
1	Islet Amyloid PolypeptideIBA 08/2014
1	Myelin ProteinsIBA 12/2013
1	Presenilin-1IBA 01/2013
1	Free RadicalsIBA 12/2011
1	NADPH Oxidases (NAD(P)H oxidase)IBA 12/2011
1	DNA (Deoxyribonucleic Acid)IBA 05/2011
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 09/2009

Therapy/Procedure

11	Therapeutics 10/2020 - 05/2003
4	Intraventricular Infusions 04/2006 - 01/2004
1	Estrogen Replacement Therapy 01/2013